Article

Targeting NAT10 suppresses T <sub>FH</sub> responses and alleviates allergic asthma via an ac4C-TOX2 axis

2026-07-25

Abstract excerpt

Chemical modifications of RNA, such as N4-acetylcytidine (ac⁴C), fine-tune gene expression, but their roles in cell fate determination within the immune system remain poorly understood. Here, we identify the RNA cytidine acetyltransferase NAT10 as a pivotal regulator of T follicular helper (T FH ) cell differentiation and the germinal centre response. T cell-specific ablation of Nat10 in mice severely impaired T...

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Literature Corpus work: 7810eb9b-66fe-5247-ab81-d21afa440308
DOI: 10.64898/2026.07.21.739954

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