Article

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

2024-07-16

Abstract excerpt

Epigenetic traits impact the antitumor function of CD8 T cells, yet whether and how RNA methylation programs engage in T cell immunity is poorly understood. Here we show that the N 6 -methyladenosine (m 6 A) RNA reader YTHDF2 is highly expressed in early effector or effector-like CD8 T cells and is partially distributed in the nucleus. YTHDF2 loss in T cells exacerbates tumor progression and confers unresponsive...

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Literature Corpus work: e323b57f-efed-5094-bc21-97af682ca6c6
DOI: 10.1101/2024.07.11.603088

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