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Article

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.

Nature communications - 27 Apr 2020

Bilska Aleksandra, Kusio-Kobiałka Monika, Krawczyk Paweł S, Gewartowska Olga, Tarkowski Bartosz, Kobyłecki Kamil, Nowis Dominika, Golab Jakub, Gruchota Jakub, Borsuk Ewa, Dziembowski Andrzej, Mroczek Seweryn

Abstract excerpt

TENT5C is a non-canonical cytoplasmic poly(A) polymerase highly expressed by activated B cells to suppress their proliferation. Here we measure the global distribution of poly(A) tail lengths in responsive B cells using a Nanopore direct RNA-sequencing approach, showing that TENT5C polyadenylates immunoglobulin mRNAs regulating their half-life and consequently steady-state levels. TENT5C is upregulated in...

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Identifiers

PMID: 32341344
DOI: 10.1038/s41467-020-15835-3
PMCID: PMC7184606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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