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Article

Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond

30 Jun 2025

Abstract excerpt

-acetylcytidine (ac4C), a conserved RNA modification, plays critical roles in RNA stability and translation. As the primary enzyme catalyzing ac4C, N-acetyltransferase 10 (NAT10) is increasingly implicated in diverse diseases. This review systematically explores NAT10's multifaceted contributions to cancer, autoimmune disorders, infectious diseases, cardiovascular conditions, and metabolic syndromes. In cancer,...

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PMID: 40588654
DOI: 10.1186/s43556-025-00286-3

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