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Article

Pleotropic effects of PPARD accelerate colorectal tumor progression and invasion

2018-05-24

Abstract excerpt

Colorectal carcinogenesis (CRC) progression requires additional molecular mechanisms to APC mutations/aberrant β-catenin signaling. PPARD is a druggable ligand-activated nuclear receptor that regulates essential genes involved in cell fate. PPARD is upregulated in intestinal epithelial cells (IECs) of human colorectal adenomas and adenocarcinomas. The mechanistic significance of PPARD upregulation in CRC remains u...

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Literature Corpus work
c15d6494-f012-5d08-b49f-6693d1bd70d8
DOI
10.1101/325001
Open publication

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Pleotropic effects of PPARD accelerate colorectal tumor progression and invasionDOI 10.1101/325001
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