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Article

Mir34a constrains pancreatic carcinogenesis.

Scientific reports - 15 Jun 2020

Hidalgo-Sastre Ana, Lubeseder-Martellato Clara, Engleitner Thomas, Steiger Katja, Zhong Suyang, Desztics Judit, Öllinger Rupert, Rad Roland, Schmid Roland M, Hermeking Heiko, Siveke Jens T, von Figura Guido

Abstract excerpt

Several studies have shown that over 70 different microRNAs are aberrantly expressed in pancreatic ductal adenocarcinoma (PDAC), affecting proliferation, apoptosis, metabolism, EMT and metastasis. The most important genetic alterations driving PDAC are a constitutive active mutation of the oncogene Kras and loss of function of the tumour suppressor Tp53 gene. Since the MicroRNA 34a (Mir34a) is a direct target of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32541781
DOI: 10.1038/s41598-020-66561-1
PMCID: PMC7295749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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