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Article

Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras.

American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2020

Asahina Kinji, Balog Steven, Hwang Edward, Moon Eugene, Wan Emily, Skrypek Kaitlin, Chen Yibu, Fernandez Jay, Romo Janet, Yang Qihong, Lai Keane, French Samuel W, Tsukamoto Hidekazu

Abstract excerpt

Kras mutations are associated with pancreatic ductal adenocarcinoma (PDAC). Although tobacco smoking, pancreatitis, and obesity are known environmental risk factors for PDAC, the contribution of moderate alcohol intake to PDAC remains elusive. In the present study, we tested whether a combination of risk factors or moderate alcohol intake induces PDAC development in mice. Control Pdx1Cre and Pdx1Cre;LSL-KrasG12D...

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Source

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Identifiers

PMID: 31760766
DOI: 10.1152/ajpgi.00218.2019
PMCID: PMC7052574

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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