Article
Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.
PloS one - 1 Jan 2017
Chang Hui-Hua, Moro Aune, Takakura Kazuki, Su Hsin-Yuan, Mo Allen, Nakanishi Masako, Waldron Richard T, French Samuel W, Dawson David W, Hines O Joe, Li Gang, Go Vay Liang W, Sinnett-Smith James, Pandol Stephen J, Lugea Aurelia, Gukovskaya Anna S, Duff Michael O, Rosenberg Daniel W, Rozengurt Enrique, Eibl Guido
Abstract excerpt
Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic cancer, a high-fat, high-calorie diet (HFCD) was given to P48+/Cre;LSL-KRASG12D (KC) mice carrying a pancreas-specific oncogenic Kras mutation. The mice were randomly allocated...
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