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Article

Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion

24 Jan 2019

Abstract excerpt

Abstract APC mutations activate aberrant β-catenin signaling to drive initiation of colorectal cancer; however, colorectal cancer progression requires additional molecular mechanisms. PPAR-delta (PPARD), a downstream target of β-catenin, is upregulated in colorectal cancer. However, promotion of intestinal tumorigenesis following deletion of PPARD in Apcmin mice has raised questions about the effects of PPARD on...

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PMID: 30679176
DOI: 10.1158/0008-5472.can-18-1790

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