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Article

Inactivation of Smad4 Accelerates KrasG12D-Mediated Pancreatic Neoplasia

1 Sept 2007

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal human malignancies, with an overall 5-year survival rate of <5%. Genetic analysis of PDAC patient samples has shown that specific disease-associated mutations are correlated with histologically defined stages of neoplastic progression in the ductal epithelium. Activating mutations in KRAS are almost uniformly present in early-stage disease, with...

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PMID: 17804724
DOI: 10.1158/0008-5472.can-06-4167

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