Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.

Cancer prevention research (Philadelphia, Pa.) - 1 Oct 2013

Dawson David W, Hertzer Kathleen, Moro Aune, Donald Graham, Chang Hui-Hua, Go Vay Liang, Pandol Steven J, Lugea Aurelia, Gukovskaya Anna S, Li Gang, Hines Oscar J, Rozengurt Enrique, Eibl Guido

Abstract excerpt

There is epidemiologic evidence that obesity increases the risk of cancers. Several underlying mechanisms, including inflammation and insulin resistance, are proposed. However, the driving mechanisms in pancreatic cancer are poorly understood. The goal of the present study was to develop a model of diet-induced obesity and pancreatic cancer development in a state-of-the-art mouse model, which resembles important...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Pancreatic Ductal
Share to Chemokines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Energy Intake

Share to Fibronectins

Share to Insulin Resistance

Share to Pancreatic Neoplasms

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23943783
DOI: 10.1158/1940-6207.CAPR-13-0065
PMCID: PMC3835151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.PMID 23943783Read ↗

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice.Semantic proximity Read ↗

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras.Semantic proximity Read ↗

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Physical Activity Delays Obesity-Associated Pancreatic Ductal Adenocarcinoma in Mice and Decreases InflammationSemantic proximity Read ↗

Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.Semantic proximity Read ↗

Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant <i>Kras</i> MiceSemantic proximity Read ↗

Endogenous insulin contributes to pancreatic cancer developmentSemantic proximity Read ↗

E-cadherin expression in obesity-associated, Kras-initiated pancreatic ductal adenocarcinoma in mice.Semantic proximity Read ↗

A mouse model of diet-induced obesity and insulin resistance.Semantic proximity Read ↗

Obesity and Cancer: The Oil that Feeds the Flame.Semantic proximity Read ↗

High-fat diet imprints a macrophage-tumor CAMP-P2RX7 axis driving pancreatic cancer initiation, plasticity and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.