Article

High-fat diet imprints a macrophage-tumor CAMP-P2RX7 axis driving pancreatic cancer initiation, plasticity and metastasis

2026-02-11

Abstract excerpt

High-fat diet (HFD) and obesity are increasingly recognized as risk factors of pancreatic ductal adenocarcinoma (PDAC), yet the mechanisms by which dietary fat contribute to oncogenic transformation remain elusive. Using an inducible acinar-specific Kras G12V / Trp53 -loss genetically-engineered mouse model of PDAC, we established early-and late-onset protocols to assess age-dependent susceptibility to HFD. Spe...

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Literature Corpus work: 47d7e0cd-bc7a-5dc1-842e-9c342e96ed1f
DOI: 10.64898/2026.02.10.703309

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