Article

Characterization of astrocyte density in the Pitt-Hopkins Syndrome mouse model of ASD

2025-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factor 4 (TCF4) is a proneural basic helix-loop-helix transcription factor that plays a critical role in brain development and is associated with a variety of psychiatric disorders including autism spectrum disorder (ASD), major depressive disorder, and schizophrenia. Autosomal dominant mutations in TCF4 result in a profound neurodevelopmental disorder called Pitt-Hopkins Syndrome...

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Literature Corpus work: 77edc29f-aa6b-5c42-b838-ea2cb8efac7b
DOI: 10.1101/2025.07.10.664109

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