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Article

Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.

Molecular psychiatry - 1 Nov 2023

Chen Huei-Ying, Phan BaDoi N, Shim Gina, Hamersky Gregory R, Sadowski Norah, O'Donnell Thomas S, Sripathy Srinidhi Rao, Bohlen Joseph F, Pfenning Andreas R, Maher Brady J

Abstract excerpt

Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor that is implicated in a variety of psychiatric disorders including autism spectrum disorder (ASD), major depression, and schizophrenia. Autosomal dominant mutations in TCF4 are causal for a specific ASD called Pitt-Hopkins Syndrome (PTHS). However, our understanding of etiological and pathophysiological mechanisms downstream of TCF4...

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Identifiers

PMID: 37770578
DOI: 10.1038/s41380-023-02248-z
PMCID: PMC11144438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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