Article
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
Neuron - 21 Jul 2005
Hoshino Mikio, Nakamura Shoko, Mori Kiyoshi, Kawauchi Takeshi, Terao Mami, Nishimura Yoshiaki V, Fukuda Akihisa, Fuse Toshimitsu, Matsuo Naoki, Sone Masaki, Watanabe Masahiko, Bito Haruhiko, Terashima Toshio, Wright Christopher V E, Kawaguchi Yoshiya, Nakao Kazuwa, Nabeshima Yo-Ichi
Abstract excerpt
The molecular machinery governing glutamatergic-GABAergic neuronal subtype specification is unclear. Here we describe a cerebellar mutant, cerebelless, which lacks the entire cerebellar cortex in adults. The primary defect of the mutant brains was a specific inhibition of GABAergic neuron production from the cerebellar ventricular zone (VZ), resulting in secondary and complete loss of external germinal layer,...
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