Article

<i>Tcf4</i> Deficiency Causes Recurrent Seizures in Mice

2024-11-01

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factor 4 (TCF4) is a transcription factor that is critical for the normal development and function of the central nervous system. Haploinsufficiency of TCF4 causes Pitt-Hopkins Syndrome (PTHS), a lifelong neurodevelopmental disorder characterized by seizures and intellectual disability. To expand our currently limited understanding of TCF4 function and PTHS pathophysiology, we cre...

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Literature Corpus work: 3c1a73e9-05a5-53c3-85a6-103c1bc15f96
DOI: 10.1101/2024.11.01.621590

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