Article

<i>Tcf4</i> encodescortical differentiation during development

2018-11-14

Abstract excerpt

Tcf4 has been linked to autism, schizophrenia, and Pitt-Hopkins Syndrome (PTHS) in humans, however, the mechanisms behind its role in disease development is still elusive. In the present study, we provide evidence that Tcf4 has a critical function in the differentiation of cortical regions during development. We show that Tcf4 is present throughout the developing brain at the peak of neurogenesis. Deletion of...

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Literature Corpus work: 7ae9aaf8-8bd7-5fb2-bd16-10e4cc6a80ad
DOI: 10.1101/470385

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