Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MeCP2 Deficiency Leads to Loss of Glial Kir4.1

1 Jan 2018

Abstract excerpt

Abstract Rett syndrome (RTT) is an X-linked neurodevelopmental disorder usually caused by mutations in methyl-CpG-binding protein 2 (MeCP2). RTT is typified by apparently normal development until 6–18 mo of age, when motor and communicative skills regress and hand stereotypies, autonomic symptoms, and seizures present. Restoration of MeCP2 function selectively to astrocytes reversed several deficits in a murine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune Neurological Disorders and Treatments
Share to Chromatin Remodeling and Cancer
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29464197
DOI: 10.1523/eneuro.0194-17.2018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MeCP2 Deficiency Leads to Loss of Glial Kir4.1PMID 29464197Read ↗

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.Semantic proximity Read ↗

<i>Mecp2</i> knock-out astrocytes affect synaptogenesis by IL-6 dependent mechanismsSemantic proximity Read ↗

The story of Rett syndrome: from clinic to neurobiology.Semantic proximity Read ↗

Impaired astrocyte-to-neuron cholesterol trafficking drives synaptic dysfunction in Rett syndromeSemantic proximity Read ↗

Developmental Dynamics of Rett Syndrome.Semantic proximity Read ↗

The Exon Junction Complex Factor RBM8A in Glial Fibrillary Acid Protein-Expressing Astrocytes Modulates Locomotion BehaviorsSemantic proximity Read ↗

Epigenetic Dysregulation in Rett Syndrome: Multisystem Pathophysiology, MECP2 Isoform-Specific Mechanisms, and Targeted Therapeutic StrategiesSemantic proximity Read ↗

Epigenetic Dysregulation in Rett Syndrome: Multisystem Pathophysiology, MECP2 Isoform-Specific Mechanisms, and Targeted Therapeutic StrategiesSemantic proximity Read ↗

MeCP2 mutant protein is expressed in astrocytes as well as in neurons and localizes in the nucleus.Semantic proximity Read ↗

Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.Semantic proximity Read ↗

Activity-Induced MeCP2 Phosphorylation Regulates Retinogeniculate Synapse RefinementSemantic proximity Read ↗

Rett and Rett-related disorders: Common mechanisms for shared symptoms?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.