Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.

Molecular brain - 27 May 2015

Andoh-Noda Tomoko, Akamatsu Wado, Miyake Kunio, Matsumoto Takuya, Yamaguchi Ryo, Sanosaka Tsukasa, Okada Yohei, Kobayashi Tetsuro, Ohyama Manabu, Nakashima Kinichi, Kurosawa Hiroshi, Kubota Takeo, Okano Hideyuki

Abstract excerpt

BACKGROUND: Rett syndrome (RTT) is one of the most prevalent neurodevelopmental disorders in females, caused by de novo mutations in the X-linked methyl CpG-binding protein 2 gene, MECP2. Although abnormal regulation of neuronal genes due to mutant MeCP2 is thought to induce autistic behavior and impaired development in RTT patients, precise cellular mechanisms underlying the aberrant neural progression remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl-CpG-Binding Protein 2

Share to Multipotent Stem Cells

Share to Neural Stem Cells

Share to Rett Syndrome

Share to Twins, Monozygotic

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 26012557
DOI: 10.1186/s13041-015-0121-2
PMCID: PMC4446051

Genes

GFAP
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.PMID 26012557Read ↗

MeCP2 Deficiency Leads to Loss of Glial Kir4.1Semantic proximity Read ↗

Modeling Rett Syndrome with Human Pluripotent Stem Cells: Mechanistic Outcomes and Future Clinical Perspectives.Semantic proximity Read ↗

Generation of functional iPSC-derived astrocytes to model the neurodevelopmental disorder, Rett SyndromeSemantic proximity Read ↗

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons.Semantic proximity Read ↗

Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.Semantic proximity Read ↗

Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology.Semantic proximity Read ↗

Human TSC2 Mutant Cells Exhibit Aberrations in Early Neurodevelopment Accompanied by Changes in the DNA MethylomeSemantic proximity Read ↗

Identification of Human Pluripotent Stem Cell Derived Astrocytic Progenitors that Correlate with Glioblastoma SubtypesSemantic proximity Read ↗

Human iPSC-derived neural stem cells display a radial glia-like signature <i>in vitro</i> and favorable long-term safety in transplanted miceSemantic proximity Read ↗

MECP2T203M mutation disrupts neurogenesis in human cerebral organoids by altering chromatin dynamics and transcriptional regulation.Semantic proximity Read ↗

<i>Mecp2</i> knock-out astrocytes affect synaptogenesis by IL-6 dependent mechanismsSemantic proximity Read ↗

Human TSC2 mutant cells exhibit aberrations in early neurodevelopment accompanied by changes in the DNA Methylome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.