Article
A novel human organoid model system reveals requirement of TCF4 for oligodendroglial differentiation.
Life science alliance - 1 Jun 2025
Furlanetto Federica, Flegel Nicole, Kremp Marco, Spear Chiara, Fröb Franziska, Alfonsetti Margherita, Bohl Bettina, Krumbiegel Mandy, Turan Sören, Reis Andre, Lie Dieter C, Winkler Jürgen, Falk Sven, Wegner Michael, Karow Marisa
Abstract excerpt
Heterozygous mutations of TCF4 in humans cause Pitt-Hopkins syndrome, a neurodevelopmental disease associated with intellectual disability and brain malformations. Although most studies focus on the role of TCF4 in neural stem cells and neurons, we here set out to assess the implication of TCF4 for oligodendroglial differentiation. We discovered that both monoallelic and biallelic mutations in TCF4 result in a...
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