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Article

Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.

PloS one - 1 Jan 2015

Solti Izabella, Kvell Krisztian, Talaber Gergely, Veto Sara, Acs Peter, Gallyas Ferenc, Illes Zsolt, Fekete Katalin, Zalan Petra, Szanto Arpad, Bognar Zita

Abstract excerpt

Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions. Peripheral T-cell function in the cuprizone model has already been explored; therefore, in the present study, we investigated, for the first time, how cuprizone feeding affects the thymus, the organ of T-cell maturation and selection. We found that even one...

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Source

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Identifiers

PMID: 26053248
DOI: 10.1371/journal.pone.0129217
PMCID: PMC4460035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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