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18β-Glycyrrhetinic acid alleviates demyelination by modulating the microglial M1/M2 phenotype in a mouse model of cuprizone-induced demyelination.

Neuroscience letters - 11 Jun 2021

Tian Hui, Cheng Yahong, Zhang Yiyuan, Bai Xinying, Jiang Yuan, Li Jinjin, Fan Shiqi, Ding Hong

Abstract excerpt

This research aimed to examine the nutritious supplementary function of 18β-Glycyrrhetinic acid (18β-GA) in moderating the myelin sheath destruction and behavioral impairments observed in the cuprizone model of demyelination. Mice were fed daily on food containing cuprizone (0.3 %) and given doses of 18β-GA (5 or 1 mg/kg) for a period of five weeks. The groups treated with 18β-GA exhibited improvements in...

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Demyelinating Diseases
Locomotion
Mice
Mice, Inbred C57BL
Microglia

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PMID: 33812928
DOI: 10.1016/j.neulet.2021.135871

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