Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 May 2012

Mancuso Renzo, Oliván Sara, Mancera Pilar, Pastén-Zamorano Andrea, Manzano Raquel, Casas Caty, Osta Rosario, Navarro Xavier

Abstract excerpt

Knowledge of the potential effect of genetic background in disease models is important. The SOD1-G93A transgenic mouse is the most widely used model in amyotrophic lateral sclerosis (ALS). Since these animals show considerable variability both in the onset and the progression of the disease, this study aimed to characterize the potential differences between the two most widely used strains, C56BL/6 (B6) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Evoked Potentials, Motor

Share to Mice, Transgenic

Share to Superoxide Dismutase

Share to Survival Analysis

Source

Identifiers

PMID: 22424126
DOI: 10.3109/17482968.2012.662688

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis.PMID 22424126Read ↗

Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: a window of opportunity in the search for genetic modifiers.Semantic proximity Read ↗

New Insights on the Mechanisms of Disease Course Variability in ALS from Mutant SOD1 Mouse Models.Semantic proximity Read ↗

A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosisSemantic proximity Read ↗

Delineating sex-dependent and anatomic decline of motor functions in the SOD1G93A mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

Comparative study of behavioural tests in the SOD1G93A mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Optimal methods to characterize the G93A mouse model of ALS.Semantic proximity Read ↗

Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS.Semantic proximity Read ↗

Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease.Semantic proximity Read ↗

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.Semantic proximity Read ↗

Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model.Semantic proximity Read ↗

Optimised and Rapid Pre-clinical Screening in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis (ALS)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.