Article

G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer

2024-06-28

Abstract excerpt

Epigenetic evolution is a common mechanism used by cancer cells to evade the therapeutic effects of drug treatment. In ovarian cancers, epigenetically-driven resistance may be responsible for a large number of late-stage patient deaths. Here, we describe the first investigation into the role of G-quadruplex (G4) DNA secondary structures in mediating epigenetic regulation in drug-resistant ovarian cancer cells. Thr...

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Identifiers and source

Literature Corpus work: 3648a8c9-ee5c-56e3-84cd-8887af0d25e7
DOI: 10.1101/2024.06.24.600010

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