Article

Genome-wide mapping of DNA G-quadruplexes in <i>Trypanosoma brucei</i> chromatin reveals enrichment in coding regions

2025-07-22

Abstract excerpt

<h4>ABSTRACT</h4> G-quadruplexes (G4s) are non-canonical DNA structures formed in guanine-rich sequences that are proposed to act as regulatory elements in trypanosomatid parasites, including Trypanosoma brucei , the causative agent of African sleeping sickness. However, their functional roles remain poorly understood, largely due to limited knowledge of their genomic distribution. Herein, we performed computati...

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Literature Corpus work: 53e2ab63-aae5-5334-b037-79a8d7e96c0d
DOI: 10.1101/2025.07.22.666098

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