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Beyond Genotype: Multidomain Biomarker-Integrated Risk Scores Reveal Prognostic phenotypes Among Individuals with High-Risk <i>APOL1</i> Genotypes

2026-06-05

Abstract excerpt

<h4>Introduction</h4> APOL1 high-risk variants markedly increase susceptibility to kidney disease among individuals of African ancestry; however, only a subset of carriers develops clinically significant CKD or ESKD. This discrepancy highlights a gap between genetic risk and clinical trajectory. Current prognostic tools rely primarily on eGFR and albuminuria, which incompletely reflect the underlying biological p...

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Literature Corpus work: 77a4c697-e49b-5781-9dc2-06b06d5a7a62
DOI: 10.64898/2026.06.03.26354877

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