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Article

APOL1-associated kidney disease: modulators of the genotype-phenotype relationship.

Current opinion in nephrology and hypertension - 1 May 2025

Pollak Martin R, Friedman David J

Abstract excerpt

PURPOSE OF REVIEW: Apolipoprotein-L1 (APOL1) G1 and G2 risk variants, found in people of recent west sub-Saharan African ancestry, dramatically increase the likelihood of kidney disease, yet the incomplete penetrance an diverse clinical manifestations underscore the need to understand the molecular and environmental factors that modulate APOL1-mediated toxicity. RECENT FINDINGS: Recent studies confirm that risk...

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Source

Identifiers

PMID: 40047214
DOI: 10.1097/MNH.0000000000001068

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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