Article

Quantifying the genetic contributions in unexplained kidney failure reveals<i>APOL1-HLA</i>interaction

2024-10-13

Abstract excerpt

<h4>Background</h4> Unexplained kidney failure (uKF) affects 15% of individuals requiring kidney replacement therapy. Absence of a diagnosis creates uncertainty around recurrence after transplantation, familial risk, and participation in therapeutic trials. Whole genome sequencing (WGS) was used to identify genetic variants contributing to uKF. <h4>Methods</h4> 218 patients who presented with uKF < 50 years old we...

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Literature Corpus work: b649606a-f66f-59b6-b51e-3aea72cd8234
DOI: 10.1101/2024.10.10.24315080

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