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Article

APOL1 Kidney Risk Variants and Proteomics.

Clinical journal of the American Society of Nephrology : CJASN - 1 May 2022

Chen Teresa K, Surapaneni Aditya L, Arking Dan E, Ballantyne Christie M, Boerwinkle Eric, Chen Jingsha, Coresh Josef, Köttgen Anna, Susztak Katalin, Tin Adrienne, Yu Bing, Grams Morgan E

Abstract excerpt

BACKGROUND AND OBJECTIVES: The APOL1 risk variants (G1 and G2) are associated with kidney disease among Black adults, but the clinical presentation is heterogeneous. In mouse models and cell systems, increased gene expression of G1 and G2 confers cytotoxicity. How APOL1 risk variants relate to the circulating proteome warrants further investigation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 461 African...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Matrix Metalloproteinase 2

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Source

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Identifiers

PMID: 35474272
DOI: 10.2215/CJN.14701121
PMCID: PMC9269576

Genes

APOL1
APOL2
CLSTN2
SPOCK2

Provenance

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