Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.

doi:10.1038/s41591-026-04337-2

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Article

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes.

Nature medicine - 1 May 2026

Li Chenyu, Richards Shola M, Quinn Ghazal, Abedini Amin, Zhu Minyan, Verma Tanya, Mohandes Samer, Pitts Rebecca, Barros Vesna, Qiu Xiazi, Shin Taehwan, Loureiro Joseph J, Finkel Nancy, Surapaneni Aditya, Coresh Josef, Grams Morgan E, Karihaloo Anil, Li Hongzhe, Verma Anurag, Ritchie Marylyn, Rader Daniel J, Dietrich William F, Jennings Lori L, Susztak Katalin

Abstract excerpt

Individuals of African ancestry carrying APOL1 (apolipoprotein L1) high-risk genotypes face a markedly increased risk of kidney failure, yet tools to identify those individuals likely to progress to chronic kidney disease are lacking. Here we profiled plasma proteomes of 851 Penn Medicine BioBank participants of African ancestry (285 males and 566 females) with APOL1 high-risk genotypes and preserved estimated...

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Identifiers

PMID: 41986737
DOI: 10.1038/s41591-026-04337-2
PMCID: PMC13190321

Genes

APOL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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