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Bivalent chromatin as a therapeutic target in cancer: An <i>in silico</i> predictive approach for combining epigenetic drugs

2020-10-15

Abstract excerpt

Tumour cell heterogeneity is a major barrier for efficient design of targeted anti-cancer therapies. A diverse distribution of phenotypically distinct tumour-cell subpopulations prior to drug treatment predisposes to non-uniform responses, leading to the elimination of sensitive cancer cells whilst leaving resistant subpopulations unharmed. Few strategies have been proposed for quantifying the variability associat...

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Literature Corpus work
77a18cfc-3485-52a9-9fca-915a43f36fe1
DOI
10.1101/2020.10.15.340679
Open publication

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