Article
Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy.
Current drug targets - 1 Oct 2010
Heng H H, Liu G, Stevens J B, Bremer S W, Ye K J, Ye C J
Abstract excerpt
Based on the gene and pathway centric concept of cancer, current approaches to cancer drug treatment have been focused on key molecular targets specific and essential for cancer progression and drug resistance. This approach appears promising in many experimental models but unfortunately has not worked well in the vast majority of cancers in clinical settings. Many new proposals, based on the same rationale of...
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