Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic modulation reveals differentiation state specificity of oncogene addiction.

Nature communications - 9 Mar 2021

Khaliq Mehwish, Manikkam Mohan, Martinez Elisabeth D, Fallahi-Sichani Mohammad

Abstract excerpt

Hyperactivation of the MAPK signaling pathway motivates the clinical use of MAPK inhibitors for BRAF-mutant melanomas. Heterogeneity in differentiation state due to epigenetic plasticity, however, results in cell-to-cell variability in the state of MAPK dependency, diminishing the efficacy of MAPK inhibitors. To identify key regulators of such variability, we screen 276 epigenetic-modifying compounds,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenomics
Share to Histone Demethylases
Share to Jumonji Domain-Containing Histone Demethylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Melanocytes

Share to Melanoma

Share to Mice, Nude

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 33750776
DOI: 10.1038/s41467-021-21784-2
PMCID: PMC7943789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic modulation reveals differentiation state specificity of oncogene addiction.PMID 33750776Read ↗

Epigenetic modulation reveals differentiation state specificity of oncogene addictionSemantic proximity Read ↗

The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivitySemantic proximity Read ↗

Divergent BRAF Inhibitor Resistance Mechanisms Revealed through Epigenetic Mapping.Semantic proximity Read ↗

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancerSemantic proximity Read ↗

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells.Semantic proximity Read ↗

Dynamical modelling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneitySemantic proximity Read ↗

Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell lineSemantic proximity Read ↗

Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant MelanomaSemantic proximity Read ↗

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.Semantic proximity Read ↗

Quantitative landscapes reveal trajectories of cell-state transitions associated with drug resistance in melanomaSemantic proximity Read ↗

Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.Semantic proximity Read ↗

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.