Article
Mechanisms of action and resistance in histone methylation-targeted therapy.
Nature - 1 Mar 2024
Yamagishi Makoto, Kuze Yuta, Kobayashi Seiichiro, Nakashima Makoto, Morishima Satoko, Kawamata Toyotaka, Makiyama Junya, Suzuki Kako, Seki Masahide, Abe Kazumi, Imamura Kiyomi, Watanabe Eri, Tsuchiya Kazumi, Yasumatsu Isao, Takayama Gensuke, Hizukuri Yoshiyuki, Ito Kazumi, Taira Yukihiro, Nannya Yasuhito, Tojo Arinobu, Watanabe Toshiki, Tsutsumi Shinji, Suzuki Yutaka, Uchimaru Kaoru
Abstract excerpt
Epigenomes enable the rectification of disordered cancer gene expression, thereby providing new targets for pharmacological interventions. The clinical utility of targeting histone H3 lysine trimethylation (H3K27me3) as an epigenetic hallmark has been demonstrated1-7. However, in actual therapeutic settings, the mechanism by which H3K27me3-targeting therapies exert their effects and the response of tumour cells...
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