Article
Drug resistance and tumor heterogeneity: cells and ensembles
31 May 2025
Abstract excerpt
The population of cells that make up a tumor, and of their biomolecular conformational ensembles, are heterogeneous at all levels, genetic, epigenetic, and phenotypic. At the cellular level, tumor heterogeneity was described as the "Rosetta Stone of therapy resistance." At the genetic level, tumors consist of divergent tumor (sub)clones. At the phenotypic level, their observed function, clinical attributes, and...
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