Article

Stochastic Population Dynamics of Cancer Stemness and Adaptive Response to Therapies

2022-07-04

Abstract excerpt

Intratumoral heterogeneity can exist along multiple axes: Cancer Stem Cells (CSCs)/non-CSCs, drug-sensitive/drug-tolerant states and a spectrum of epithelial-hybrid-mesenchymal phenotypes. Further, these diverse cell-states can switch reversibly among one another, thereby posing a major challenge to therapeutic efficacy. Therefore, understanding the origins of phenotypic plasticity and heterogeneity remains an act...

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Literature Corpus work: 91390d77-f1c6-5ac9-9cc3-d65a74ce88e8
DOI: 10.20944/preprints202207.0031.v1

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