Article

Long-read Oxford Nanopore sequencing reveals complex rearrangements and regulatory disruption in malignant pleural mesothelioma

2026-06-02

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a rare malignancy characterised by extensive structural genomic alterations and a low burden of recurrent single nucleotide variants. However, the full spectrum and functional impact of structural variation (SVs) remain incompletely understood because short-read sequencing has limitation ability to resolve complex genomic rearrangements. Here, we performed integrated short-r...

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Literature Corpus work: 779c4b94-12a7-58c3-8062-039af71f6d9e
DOI: 10.64898/2026.05.26.26353864

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