Article
Transcriptome sequencing of malignant pleural mesothelioma tumors.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2008
Sugarbaker David J, Richards William G, Gordon Gavin J, Dong Lingsheng, De Rienzo Assunta, Maulik Gautam, Glickman Jonathan N, Chirieac Lucian R, Hartman Mor-Li, Taillon Bruce E, Du Lei, Bouffard Pascal, Kingsmore Stephen F, Miller Neil A, Farmer Andrew D, Jensen Roderick V, Gullans Steven R, Bueno Raphael
Abstract excerpt
Cancers arise by the gradual accumulation of mutations in multiple genes. We now use shotgun pyrosequencing to characterize RNA mutations and expression levels unique to malignant pleural mesotheliomas (MPMs) and not present in control tissues. On average, 266 Mb of cDNA were sequenced from each of four MPMs, from a control pulmonary adenocarcinoma (ADCA), and from normal lung tissue. Previously observed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.