Article

Nanopore Sequencing Unveils Somatic Structural Variations as Biomarkers in Laryngeal squamous cell carcinoma Genomes

2025-06-17

Abstract excerpt

Laryngeal squamous cell carcinoma (LSCC) is an aggressive cancer with poor quality of life, largely due to the absence of reliable molecular biomarkers for early diagnosis and prognosis. While somatic structural variations (SVs) have been documented in LSCC, conventional short-read sequencing approaches are inherently limited in detecting of large-scale somatic SVs, which are critical to understanding tumorigenesi...

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Literature Corpus work: 2b33886c-a1cb-5b70-8809-0de507b844f2
DOI: 10.1101/2025.06.12.659252

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