The phenogenomic landscapes of pleural mesothelioma tumor microenvironment predict clinical outcomes.

doi:10.1186/s12967-025-06193-z

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Article

The phenogenomic landscapes of pleural mesothelioma tumor microenvironment predict clinical outcomes.

Journal of translational medicine - 20 Feb 2025

Torricelli Federica, Spada Filomena, Bishop Cynthia, Todd Katrina, Nonaka Daisuke, Petrov Nedyalko, Barberio Manuela Terranova, Ramsay Alan G, Ellis Richard, Ciarrocchi Alessia, Apollonio Benedetta, Billè Andrea

Abstract excerpt

BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy with limited therapeutic options. To improve patients management and treatment, more precise stratification strategies are needed. This study aimed to characterize the phenogenomic landscapes of MPM and to understand their influence on patients clinical outcomes. METHODS: We conducted a phenogenomic analysis on 22 MPM patients...

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Topics

Humans
Tumor Microenvironment
Mesothelioma
Male
Female
Mesothelioma, Malignant

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Prognosis

Pleural Neoplasms

Phenomics

Middle Aged

Treatment Outcome

Aged

Lung Neoplasms

Mutation

Exome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 39980060
DOI: 10.1186/s12967-025-06193-z
PMCID: PMC11844119

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