Article

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analyses

2021-09-29

Abstract excerpt

<h4>Summary</h4> Malignant Pleural Mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Using the largest series of whole-genome sequencing data integrated with transcriptomic and epigenomic data using multi-omic factor analysis, we demonstrate that MPM heterogeneity arises from four sources of variation: tumor cell morphology, ploidy, adaptive immune response, and...

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Literature Corpus work: 2f78239b-60d0-5490-a9e3-0a130707e2e5
DOI: 10.1101/2021.09.27.461908

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