Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity

16 Mar 2023

Abstract excerpt

Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Through a large series of whole-genome sequencing data, integrated with transcriptomic and epigenomic data using multiomics factor analysis, we demonstrate that the current World Health Organization classification only accounts for up to 10% of interpatient molecular differences. Instead, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Medical Imaging and Pathology Studies
Share to Occupational and environmental lung diseases
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36928603
DOI: 10.1038/s41588-023-01321-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneityPMID 36928603Read ↗

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analysesSemantic proximity Read ↗

Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma.Semantic proximity Read ↗

Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applicationsSemantic proximity Read ↗

A molecular phenotypic map of Malignant Pleural MesotheliomaSemantic proximity Read ↗

A molecular phenotypic map of malignant pleural mesothelioma.Semantic proximity Read ↗

Redefining mesothelioma types as a continuum uncovers the immune and vascular systems as key players in the diagnosis and prognosis of this diseaseSemantic proximity Read ↗

Integrative Molecular Characterization of Malignant Pleural Mesothelioma.Semantic proximity Read ↗

Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapySemantic proximity Read ↗

Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classificationSemantic proximity Read ↗

Multiomic, Histologic, and scRNA-seq Profiling of Pleural Mesothelioma Reveals Negative Prognosis Associated With a Novel Uncommitted Molecular Phenotype.Semantic proximity Read ↗

Immune Microenvironment and Genetics in Malignant Pleural MesotheliomaSemantic proximity Read ↗

Interrogating inter- and intratumour genomic heterogeneity in mesotheliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.