Article
Integrated genomics point to immune vulnerabilities in pleural mesothelioma.
Scientific reports - 27 Sept 2021
Nastase Anca, Mandal Amit, Lu Shir Kiong, Anbunathan Hima, Morris-Rosendahl Deborah, Zhang Yu Zhi, Sun Xiao-Ming, Gennatas Spyridon, Rintoul Robert C, Edwards Matthew, Bowman Alex, Chernova Tatyana, Benepal Tim, Lim Eric, Taylor Anthony Newman, Nicholson Andrew G, Popat Sanjay, Willis Anne E, MacFarlane Marion, Lathrop Mark, Bowcock Anne M, Moffatt Miriam F, Cookson William O C M
Abstract excerpt
Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage patient-derived cells. Previously unrecognised deletions of SUFU locus (10q24.32), observed in 21% of 118 tumours, resulted in disordered expression of transcripts from Hedgehog pathways and the T-cell...
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