Article

Integrated genomics identify novel immunotherapy targets for malignant mesothelioma

2020-01-27

Abstract excerpt

<h4>Background</h4> Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective therapies. <h4>Methods</h4> In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage patient-derived cells. <h4>Results</h4> Previously unrecognised losses of SUFU locus (10q24.32), observed in 21% of 118 tumours, resulted in disorder...

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Literature Corpus work: 90b8c532-e95b-5c62-a904-0d0c1927e24a
DOI: 10.1101/2020.01.23.20018523

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