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Article

Synucleins Have Multiple Effects on Presynaptic Architecture.

Cell reports - 3 Jan 2017

Vargas Karina J, Schrod Nikolas, Davis Taylor, Fernandez-Busnadiego Ruben, Taguchi Yumiko V, Laugks Ulrike, Lucic Vladan, Chandra Sreeganga S

Abstract excerpt

Synucleins (α, β, γ-synuclein) are a family of abundant presynaptic proteins. α-Synuclein is causally linked to the pathogenesis of Parkinson's disease (PD). In an effort to define their physiological and pathological function or functions, we investigated the effects of deleting synucleins and overexpressing α-synuclein PD mutations, in mice, on synapse architecture using electron microscopy (EM) and...

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Identifiers

PMID: 28052246
DOI: 10.1016/j.celrep.2016.12.023
PMCID: PMC5510332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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