Article
Subcellular localisation of recombinant alpha- and gamma-synuclein.
Molecular and cellular neurosciences - 1 Feb 2005
Specht Christian G, Tigaret Cezar M, Rast Georg F, Thalhammer Agnes, Rudhard York, Schoepfer Ralf
Abstract excerpt
alpha-Synuclein, a protein implicated in neurodegenerative diseases and of elusive physiological function owes its name to an observed presence in presynaptic and nuclear compartments. However, its nuclear localisation has remained controversial. We expressed synuclein-eGFP fusion proteins in organotypic rat hippocampal slice cultures and murine hippocampal primary neurons using a Sindbis virus expression system....
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