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PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data Integration

2022-07-18

Abstract excerpt

Spatial transcriptomics (ST) is a powerful new approach to characterize the cellular and molecular architecture of the tumor microenvironment. Previous single-cell RNA-sequencing (scRNA-seq) studies of pancreatic ductal adenocarcinoma (PDAC) have revealed a complex immunosuppressive environment characterized by numerous cancer associated fibroblasts (CAFs) subtypes that contributes to poor outcomes. Nonetheless, t...

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Identifiers and source

Literature Corpus work
3f3e1775-8f77-5319-b63d-3db50b1fd8a2
DOI
10.1101/2022.07.16.500312
Open publication

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PanIN and CAF Transitions in Pancreatic Carcinogenesis Revealed with Spatial Data IntegrationDOI 10.1101/2022.07.16.500312
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