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Article

Distinct Epigenomic Features in End-Stage Failing Human Hearts

25 Oct 2011

Abstract excerpt

BACKGROUND: The epigenome refers to marks on the genome, including DNA methylation and histone modifications, that regulate the expression of underlying genes. A consistent profile of gene expression changes in end-stage cardiomyopathy led us to hypothesize that distinct global patterns of the epigenome may also exist. METHODS AND RESULTS: We constructed genome-wide maps of DNA methylation and histone-3 lysine-36...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 22025602
DOI: 10.1161/circulationaha.111.040071

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