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Article

Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart

19 Jan 2023

Abstract excerpt

Heart failure (HF) is characterized by global alterations in myocardial DNA methylation, yet little is known about the epigenetic regulation of the noncoding genome and potential reversibility of DNA methylation with left ventricular assist device (LVAD) therapy. Genome-wide mapping of myocardial DNA methylation in 36 patients with HF at LVAD implantation, 8 patients at LVAD explantation, and 7 nonfailing (NF)...

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PMID: 36656640
DOI: 10.1172/jci.insight.161788

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