Article

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts <i>Legionella pneumophila</i> infection

2022-07-29

Abstract excerpt

The inflammatory cytokine tumor necrosis factor (TNF) is associated with host defense against many intracellular pathogens, including Legionella pneumophila. Legionella causes the severe pneumonia Legionnaires’ Disease and predominantly affects individuals with a suppressed immune system, such as those receiving therapeutic TNF blockade to treat autoinflammatory disorders. TNF induces pro-inflammatory gene expres...

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Literature Corpus work: 77610885-9408-5e05-b1ca-a50be15db773
DOI: 10.1101/2022.07.29.501970

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TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts <i>Legionella pneumophila</i> infectionDOI 10.1101/2022.07.29.501970Read

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